Human Total MMP-1 ELISA Kit
Rat IL-18 ELISA Kit

 

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Human Total MMP-1 ELISA Kit

 

基质金属蛋白酶（matrixmetalloproteinase，MMPs），是一类锌依赖性内肽酶，可降解细胞外基质（ECM）的各种蛋白质组分。MMPs因其需要Ca²⁺、Zn²⁺等金属离子作为辅助因子而得名。MMPs家族已分离鉴别出26个成员，编号分别为MMP1～26。根据作用底物以及片断同源性，将MMPs分为6类，为胶原酶、明胶酶、基质降解素、基质溶解素、furin活化的MMP和其他分泌型MMP。MMPs由促炎细胞和子宫胎盘细胞分泌，包括成纤维细胞、成骨细胞、内皮细胞、血管平滑肌、巨噬细胞、中性粒细胞、淋巴细胞和细胞滋养细胞等。MMPs促进细胞增殖、迁移和分化，并在血管生成、细胞凋亡和组织修复中发挥作用。它们影响内皮细胞功能以及血管平滑肌细胞的迁移、增殖、Ca²⁺信号传导、收缩。MMPs还可以影响细胞表面的生物活性分子，调节各种细胞和信号通路。
 

 

 

    

Rat IL-18 ELISA Kit

 

IL-18由巨噬细胞产生，可协同IL-12诱导TNF-α的表达，促进关节炎的发生和滑膜组织的增生。IL-18刺激关节软骨细胞iNOS、COX-2、IL-6等基因的表达,诱导产生大量NO、PGE2,参与关节的炎症、损伤、退行性变等。IL-18可诱导软骨细胞生产MMP-1、MMP-3、MMP-13等而促进软骨组织的降解。此外研究证实，IL-18经NF-κB和PI3K途径上调TNF受体、VCAM-1、ICAM-1的表达，从而促进单核/巨噬细胞生产TNF-α。
 

 

 

   

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