Rockland的高特异性Epi-Plus™抗体可识别经过修饰的组蛋白和相关的细胞靶点，并通过多种检测方法进行验证。Epi-Plus™抗体对这种修饰是特别灵敏和特异的，并且对相同位点或该蛋白其他氨基酸的其他修饰没有交叉反应。免疫荧光显微技术（IF）、免疫沉淀（IP）、染色质免疫沉淀（ChIP）、免疫组织化学（IHC）和蛋白印迹（WB）的分析验证了Epi-Plus™抗体的有效性。

翻译后修饰（PTM）如组蛋白的甲基化、乙酰化和磷酸基化等都是调节基因表达调控、DNA修复、染色体凝缩和精子形成的关键部分。许多蛋白质已经被确认形成了复合物，能够调节组蛋白修饰。这个多组件的细胞机器被称为“读者、作家和橡皮擦”。这些组蛋白修饰复合物的功能变化被认为破坏了组蛋白标记的结构和水平，从而解除了基于核染色质的过程控制，最终导致致癌转化和癌症的发展。与此一致的是，组蛋白PTM的异常模式与大量的人类恶性肿瘤有关。Rockland提供了针对大多数修饰和修饰对的抗体。
 

图为组蛋白翻译后修饰图

优势：

Rockland提供染色质和核信号抗体的组合，是表观遗传学研究的高品质试剂。在严格的质量控制测试下，Rockland生产抗组蛋白PTMs的抗体。这种Epi-Plus抗体是经过多种试验验证的，包括利用修饰过的肽阵、western blots和染色质免疫沉淀（ChIP）进行的斑点印迹检测。这确保成品符合或超过我们的高标准，以达到最佳的性能。

Epi-Plus™ 抗体推荐：

用于Histone 3 K4 甲基化
 

厂商	货号	名称
Rockland	600-401-I57	Anti-Histone H3 [Monomethyl Lys4] (RABBIT) Antibody
Rockland	600-401-I58	Anti-Histone H3 [Dimethyl Lys4] (RABBIT) Antibody
Rockland	600-401-I59	Anti-Histone H3 [Trimethyl Lys4] (RABBIT) Antibody

Epi-Plus™ 部分抗体列表：

 

货号	名称	规格	种属反应
600-401-I52	Histone H3 R2me1 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I53	Histone H3 R2me2a Antibody	50ug	Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant
600-401-I54	Histone H3 K4me1/pT3 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I55	Histone H3 K4me2/pT3 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I56	Histone H3 pT3/K4ac Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I57	Histone H3 K4me1 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I58	Histone H3 K4me2 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I59	Histone H3 K4me3 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I60	Histone H3 K4ac Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I61	Histone H3 K4me1/pT6 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I62	Histone H3 K4me3/pT6 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I63	Histone H3 pT6 Antibody	50ug	Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant
600-401-I64	Histone H3 K9me1/pT6 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I65	Histone H3 K9me2/pT6 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I66	Histone H3 K9me3/pT6 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I67	Histone H3 R8me2a Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I68	Histone H3 R8me2s Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I69	Histone H3 K9me1 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I70	Histone H3 K9me2 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I71	Histone H3 K9me3 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I72	Histone H3 K9ac Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I73	Histone H3 K9ac/K14ac Antibody	50ug	Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant
600-401-I74	Histone H3 pS10 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I75	Histone H3 pS10/pT11 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I76	Histone H3 pT11 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I77	Histone H3 R17me2a Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I78	Histone H3 K18me1 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I79	Histone H3 K18me2 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I80	Histone H3 K18me3 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I81	Histone H3 K18ac Antibody	50ug	Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant
600-401-I82	Histone H3 K23ac Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I83	Histone H3 pS28 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I84	Histone H3 K27me3/pS28 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I85	Histone H3 R2me2s/K4me2   Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I86	Histone H3 K36me1 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I87	Histone H3 K36me2 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I88	Histone H3 K36me3 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I89	Histone H3 K36ac Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I90	Histone H3 K37me1 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I91	Histone H3 K37me2 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I92	Histone H3 K37me3 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I93	Histone H3 K56me1 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I94	Histone H3 K56me3 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-I95	Histone H3 K79Me3 Antibody	50ug	Human, mouse, C. elegans, rat, chicken,Xenopus, Drosophila, plant
600-401-J98	Histone H3 K4-Me3/K9-Ac Antibody	50ug	Human, mouse, rat, C. elegans
600-401-J99	Histone H3 K27me3 Antibody	50ug	Human, mouse, rat, C. elegans
600-401-K00	Histone H3 K27ac Antibody	50ug	Human, mouse, rat, C. elegans
600-401-K01	Histone H3 K4me2/pT6 Antibody	50ug	Human, mouse, rat, C. elegans
600-401-K02	Histone H3 K23me2 Antibody	50ug	Human, mouse, rat, C. elegans
600-401-M75	Histone H3 K27 methyl Antibody	50ug	Human, mouse, rat, C. elegans
600-401-P08	Histone H3 K9-Ac/pS10    (RABBIT) Antibody	50ug	Human
600-401-P10	Histone H3 K79-Me1 Antibody	50ug	Human, Mouse, Primate, C. elegans,Drosophila, Plant, Rat, Xenopus
600-401-P14	Histone H3 pT3/R2-Me2s Antibody	50ug	Human
600-401-V34	Histone H3 K27 me2 Antibody	50ug	Human
600-401-W54	Histone H3 K27 me1 Antibody	50ug	Human